Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome

Summary: Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading microorganisms through autophagic machinery.The intracellular bacterial pathogen Legionella pneumophila can avoid clearance by the xenophagy pathway via the actions of multiple Dot/Icm effector proteins.Previous studies have shown that p62, an adaptor p

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Identification and characterization of tweets related to the 2015 Indiana HIV outbreak: A retrospective infoveillance study.

IntroductionFrom late 2014 through 2015, Scott County, Indiana faced an HIV outbreak triggered by opioid abuse and transition to injection drug use.Investigating the origins, risk factors, and responses related to this outbreak is critical to inform future surveillance, interventions, and policymaking.In response, this retrospective infoveillance s

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A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans

During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input.How the brain reaches this state spontaneously is not known.General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness.

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