Robotics and autonomous systems have been dubbed as viable technological solutions to address the incessant demand for long-term care (LTC) across the world, which is exacerbated by ageing populations.However, similar to other emerging technologies, the adoption of robotics and autonomous systems in LTC pose risks and unintended consequences.In the
Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
Summary: Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading microorganisms through autophagic machinery.The intracellular bacterial pathogen Legionella pneumophila can avoid clearance by the xenophagy pathway via the actions of multiple Dot/Icm effector proteins.Previous studies have shown that p62, an adaptor p
Identification and characterization of tweets related to the 2015 Indiana HIV outbreak: A retrospective infoveillance study.
IntroductionFrom late 2014 through 2015, Scott County, Indiana faced an HIV outbreak triggered by opioid abuse and transition to injection drug use.Investigating the origins, risk factors, and responses related to this outbreak is critical to inform future surveillance, interventions, and policymaking.In response, this retrospective infoveillance s
A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans
During awake consciousness, the brain intrinsically maintains a dynamical state in which it can coordinate complex responses to sensory input.How the brain reaches this state spontaneously is not known.General anesthesia provides a unique opportunity to examine how the human brain recovers its functional capabilities after profound unconsciousness.
High-Efficiency High Voltage Hybrid Charge Pump Design With an Improved Chip Area
A hybrid charge pump was developed in elf bar airpods case a 0.13- $mu ext{m}$ Bipolar-CMOS-DMOS (BCD) process which utilised high drain-source voltage MOS devices and low-voltage integrated metal-insulator-metal (MIM) capacitors.The design consisted of a zero-reversion loss cross-coupled stage and a new self-biased serial-parallel charge pump des